Does TTF-1 positive mean cancer?

TTF-1 plays a key role in morphogenesis of the lungs[1] and is expressed in up to 90% of pulmonary small cell carcinoma[2]. This explains why this marker is frequently used to search for the primary origin of metastatic neuroendocrine tumours.

What does TTF-1 mean in lung cancer?

Thyroid transcription factor-1 (TTF-1) is a sensitive marker for pulmonary and thyroid adenocarcinomas. The aim of this work was to determine its usefulness in distinction between primary and metastatic lung adenocarcinomas.

Can a lung biopsy cause cancer to spread?

— A study of more than 2,000 patients by researchers at Mayo Clinic’s campus in Jacksonville, Florida, has dispelled the myth that cancer biopsies cause cancer to spread.

What is the survival rate of adenocarcinoma of the lung?

For Stage 1 disease, 5-year survival varies from 70% to 85%. For locally advanced disease, the survival drops to less than 30%. For distant metastases, less than 5% survive five years.

Is TTF-1 a biomarker?

Studies suggest that TTF-1 is a potential biomarker for differentiating pulmonary adenocarcinomas from non-pulmonary adenocarcinomas in pleural or other effusions11,12,13, but results from these studies have not always been consistent.

Does cancer spread fast after biopsy?

A long-held belief by a number of patients and even some physicians has been that a biopsy can cause some cancer cells to spread. While there have been a few case reports that suggest this can happen — but very rarely — there is no need for patients to be concerned about biopsies, says Dr.

Is adenocarcinoma of lung curable?

Adenocarcinoma of the lung can be cured if the entire tumor is removed surgically or destroyed with radiation. Overall, the prognosis for lung cancer that has spread is still poor. However, newer therapies have helped certain subsets of patients extend their lives.

What is immunohistochemistry with TTF-1?

Thyroid transcription factor-1 (TTF-1) is expressed in lung adenocarcinomas and thyroid carcinomas but not in adenocarcinomas arising from other sites. For patients with adenocarcinomas in the lung, TTF-1 staining is now routinely used to distinguish a primary lung cancer from a lung metastasis.