What is glycoprotein 11b 111a?

In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation.

What is the role of glycoprotein IIb IIIa receptor inhibitors in the acute care setting?

Glycoprotein IIb/IIIa (GP IIb/IIIa) inhibitors prevent platelet aggregation by blocking glycoprotein IIb/IIIa receptors; thus, they found application in the management of coronary artery disease (CAD). The available GP IIb/IIIa inhibitors include abciximab, tirofiban, and eptifibatide.

What drugs are P2Y12 inhibitors?

Antiplatelet drugs – P2Y12 inhibitors

• Aspirin is an antiplatelet drug that may be used.
• P2Y12 receptor blockers are another group of antiplatelet drugs. This group of drugs includes: clopidogrel, ticlopidine, ticagrelor, prasugrel, and cangrelor.

Can you take omeprazole and clopidogrel together?

Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Doctors should check whether patients who are taking clopidogrel are also buying over-the-counter omeprazole and consider whether other gastrointestinal therapies would be more suitable.

What are the available GP IIb/IIIa inhibitors?

The available GP IIb/IIIa inhibitors include abciximab, tirofiban, and eptifibatide. These agents, along with aspirin, are used in patients with unstable angina with PCI within 24 hours. NCBI Skip to main content Skip to navigation Resources How To About NCBI Accesskeys My NCBISign in to NCBISign Out

What is the role of GP IIb/IIIa antagonists in antiplatelet therapy?

The GP IIb/IIIa antagonists would theoretically provide excellent antiplatelet therapy in patients undergoing any of a variety of endovascular interventions during which thrombosis or thromboembolism may endanger distal perfusion in patients with peripheral vascular disease.

What is the structure of the GP IIb/IIIa receptor?

In particular, the GP IIb/IIIa receptor is a heterodimer consisting of the alpha IIb and beta 3 -subunits. By competing with fibrinogen and von Willebrand factor (vWF) for GP IIb/IIIa binding, GP IIb/IIIa antagonists interfere with platelet cross-linking and platelet-derived thrombus formation.

Are oral platelet glycoprotein IIb/IIIa receptor inhibitors effective for long-term treatment?

Oral platelet glycoprotein IIb/IIIa receptor inhibitors–Part I With the central importance of antiplatelet therapy in patients with coronary artery disease and the numerous positive trials with glycoprotein (GP) IIb/IIa inhibitors given intravenously, it was hoped that one could extend the benefit of IIb/IIIa inhibition to long-term treatment.